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| Sat, Oct 17 | MBB at Cincinnati (Exhibition) | 4:00pm |
| Fri, Oct 23 | MBB vs Baylor (Exhibition) | 7:00pm B1G+ |
| Sat, Oct 24 | FB vs Oregon | |
| Wed, Oct 28 | MBB vs UIC (Exhibition) | 7:00pm B1G+ |
Home: 2-2 | Away: 1-1 Record: 3-3 (1-2) | ||
| Date | Opponent | Result |
| Thu, Sept 3 | UAB | W 42-23 |
| Sat, Sept 12 | Duke | L 27-31 |
| Sat, Sept 19 | SIU | W 48-10 |
| Sat, Sept 26 | at Ohio State | L 19-42 |
| Sat, Oct 3 | Purdue | L 17-24 |
| Sat, Oct 10 | at Michigan State | W 38-37 OT |
| Sat, Oct 24 | Oregon | |
| Sat, Oct 31 | at Maryland | |
| Fri, Nov 6 | Nebraska | 7:00pm FOX |
| Fri, Nov 13 | at UCLA | 8:00pm FOX |
| Sat, Nov 21 | Iowa | |
| Sat, Nov 28 | at Northwestern | |
| Date | Opponent | Time/TV |
| Sat, Oct 17 | at Cincinnati (Exhibition) | 4:00pm |
| Fri, Oct 23 | Baylor (Exhibition) | 7:00pm B1G+ |
| Wed, Oct 28 | UIC (Exhibition) | 7:00pm B1G+ |
| Mon, Nov 2 | FDU | 7:00pm BTN |
| Thu, Nov 5 | Penn | 7:30pm FS1 |
| Tue, Nov 10 | at Texas Tech | |
| Fri, Nov 13 | Sam Houston | 6:00pm B1G+ |
| Tue, Nov 17 | at Duke | 6:00pm ESPN |
| Fri, Nov 20 | EIU | 8:00pm BTN |
| Mon, Nov 23 | Winthrop | 7:00pm BTN |
| Fri, Nov 27 | WKU | 5:00pm FS1 |
| Fri, Dec 4 | UConn (Chicago) | 6:00pm FOX |
| Tue, Dec 8 | at Minnesota | 6:00pm Peacock |
| Sat, Dec 12 | Penn State | 1:00pm FS1 |
| Sun, Dec 20 | Missouri (St. Louis) | 6:30pm ESPN2 |
| Tue, Dec 29 | Seattle | 6:00pm B1G+ |
| Sat, Jan 2 | at Wisconsin | 7:00pm FOX |
| Tue, Jan 5 | Purdue | 8:00pm Peacock |
| Sat, Jan 9 | Ohio State | 3:00pm CBS |
| Wed, Jan 13 | at Northwestern | 8:00pm BTN |
| Sat, Jan 16 | at Maryland | 1:00pm Peacock |
| Tue, Jan 19 | Nebraska | 8:00pm Peacock |
| Sun, Jan 24 | at Indiana | 11:00am CBS |
| Wed, Jan 27 | USC | 8:00pm BTN |
| Sat, Jan 30 | North Carolina (Nashville) | 5/5:30pm ESPN |
| Tue, Feb 2 | UCLA | 8:00pm Peacock |
| Fri, Feb 5 | Michigan State | 7:00pm FOX |
| Tue, Feb 9 | at Michigan | 6:00pm Peacock |
| Fri, Feb 12 | at Purdue | 7:00pm FOX |
| Tue, Feb 16 | Northwestern | 8:00pm BTN |
| Sat, Feb 20 | at Oregon | 4:00pm FOX |
| Tue, Feb 23 | at Washington | 9:00pm FS1 |
| Sun, Feb 28 | Wisconsin | 12:30pm CBS |
| Wed, Mar 3 | at Rutgers | 5:30pm BTN |
| Sat, Mar 6 | Iowa | 7:00pm FOX |